Title:
新規なスピロラクトン化合物及び医薬組成物
Document Type and Number:
Japanese Patent JP7142375
Kind Code:
B2
Abstract:
Provided herein are spirolactone compounds of Formula I that are useful as inhibitors of ACC1 and/or ACC2. The spirolactone compounds described herein can be used for treating a disease or disorder associated with aberrant ACC1 and/or ACC2 activities, for example, non-alcoholic steatohepatitis (NASH), acne, obesity, diabetes, and cancer. Also provided herein are pharmaceutical compositions comprising the spirolactone compound of Formula I, or pharmaceutically acceptable salt thereof.
Inventors:
Shion, Yu Shen
Guan, Hong-Pin
Juan, Wenjun
Guan, Hong-Pin
Juan, Wenjun
Application Number:
JP2020521484A
Publication Date:
September 27, 2022
Filing Date:
June 29, 2018
Export Citation:
Assignee:
Quixgen Inc.
International Classes:
C07D491/107; A61K31/192; A61K31/40; A61K31/4164; A61K31/438; A61K31/444; A61K31/616; A61K31/63; A61K31/65; A61K31/7048; A61K31/7056; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P17/00; A61P17/08; A61P17/10; A61P35/00; A61P43/00; C07D519/00
Domestic Patent References:
| JP2009502785A | ||||
| JP2010515733A | ||||
| JP2012517960A |
Foreign References:
| WO2008102749A1 | ||||
| WO2011025690A1 |
Other References:
HASHIGAKI, K. et al.,Synthesis and Structure-Activity Relationship of Spiro[isochromanpiperidine] Analogs for Inhibition of Histamine Release. IV,Chemical & Pharmaceutical Bulletin,1984年,32(9),pp. 3561-3568
Attorney, Agent or Firm:
Kimura Mitsuru
Yasushi Morikawa
Kei Sakurada
Hideki Mie
Yasushi Morikawa
Kei Sakurada
Hideki Mie