Title:
NOVEL STATE OF DIFLUNISAL AND RELATED COMPOUNDS
Document Type and Number:
Japanese Patent JPS58116440
Kind Code:
A
Abstract:
1-(alkoxy or aroxy)carbonyloxyalkyl esters of structural formula (I): wherein: R is (a) lower alkyl; (b) lower cycloalkyl; (c) unsubstituted or substituted aryl; or (d) aralkyl; R<1> is (a) hydrogen; (b) lower alkyl; (c) lower cycloalkyl; or (d) aryl; R<2> is (a) hydrogen; (b) lower alkanoyl; (c) lower alkoxycarbonyl; R<3> is (a) hydrogen; or (b) lower alkyl; and X is halo are disclosed. Those compounds are stable in aqueous medium and non-irritant to mucous embranes of mouth, throat, and stomach. Accordingly, they are useful Prodrugs of the analgesic and anti-inflammatory drug diflunisal.
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Inventors:
KONRATSUDO PII DOON
Application Number:
JP22311482A
Publication Date:
July 11, 1983
Filing Date:
December 21, 1982
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
A61K31/19; A61K31/215; A61K31/235; C07C67/11; A61K31/60; A61P17/00; A61P29/00; C07C68/06; C07C69/00; C07C69/78; C07C69/96; A61K; C07C; (IPC1-7): A61K31/235; A61K31/60; C07C67/11; C07C69/96
Attorney, Agent or Firm:
Masao Okabe
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