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Title:
NOVEL STEROID COMPOUND, ITS PREPARATION AND ANTIGEN COMPOSED OF SAID COMPOUND AND USEFUL FOR IMMUNOCHEMICAL DETERMINATION OF ESTRADIOL-3-SULFATE-17BETA- GLUCURONIDE
Document Type and Number:
Japanese Patent JPS6061596
Kind Code:
A
Abstract:

NEW MATERIAL:The compound of formula I (the group -NHBSA is bovine serum albumin residue; G is glucuronyl group of formula II).

EXAMPLE: 6-Oxoestradiol-3-sulfate-17β-glucuronide-6-( O-carboxymethyl )-oxime- BSA adduct.

USE: Antigen for producing antibody for the determination of estradiol-3-sulfate- 17β-glucuronide by immunochemical method.

PREPARATION: The compound of formula III [G' is glucuronyl(acetate-methylester)group] is sulfated and made to react with p-nitrophenol in the presence of a condensation agent. The product is made to react with bovine serum albumin to obtain an adduct, and the adduct is partially hydrolyzed to obtain the objective compound of formula I .


Inventors:
NANBARA TOSHIO
SHIMADA KAZUTAKE
Application Number:
JP17092583A
Publication Date:
April 09, 1985
Filing Date:
September 16, 1983
Export Citation:
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Assignee:
EIKEN CHEMICAL
International Classes:
C07J17/00; A61K39/385; C07K1/107; C07K1/113; C07K14/00; C07K14/76; C07K16/00; G01N33/53; (IPC1-7): A61K39/385; C07J17/00
Attorney, Agent or Firm:
Rikichi Ichikawa