Title:
NOVEL STEROID, ITS PRODUCTION, AND COSMETIC AND MEDICINAL COMPOSITION CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPH08134095
Kind Code:
A
Abstract:
PURPOSE: To obtain a novel steroid which is useful for a cosmetic and an anticancer agent because of its keratinization enzyme promotion action and anticancer action by reaction of 20-formyl-6-oxo-2,3,14,20-tetrahydroxypregn-7-ene with a Grignard's agent.
CONSTITUTION: This novel steroid is (+)-2β,3β,20β(22R)-pentahydroxy-(24S)- methyl-5β-cholest-7-ene-6-one having keratinization enzyme promotion and antitumor actions, thus is useful as an active ingredient in cosmetics, particularly scalp hair cosmetics and an anticancer agent. This steroid is obtained by reaction of 2-methyl-isovaleryl magnesium bromide (a Grignard's reagent obtained from 2-methylisovaleryl bromide and magnesium) with 20-formyl-6-oxo-2,3,14,20- tetrahydroxypregn-7-ene.
Inventors:
SHIBATANI JUNICHI
OKADA MASANORI
INAOKA YASUNORI
TSUJI KUNIO
OKADA MASANORI
INAOKA YASUNORI
TSUJI KUNIO
Application Number:
JP27151594A
Publication Date:
May 28, 1996
Filing Date:
November 04, 1994
Export Citation:
Assignee:
POLA CHEM IND INC
TSUJI KUNIO
TSUJI KUNIO
International Classes:
A61K8/63; A61K8/00; A61K31/575; A61P35/00; A61P43/00; A61Q5/00; A61Q7/00; A61Q19/00; C07J9/00; C07J75/00; (IPC1-7): C07J9/00; A61K7/00; A61K7/06; A61K7/48; A61K31/575; C07J75/00
Attorney, Agent or Firm:
Tsutomu Toyama (2 outside)