PURPOSE: To provide novel substances urauchimycins A or B having antifungal activities.
CONSTITUTION: The compound of the formula (when R1 is methyl and R2 is H, the formula means urauchimycin A, while in the case R1 is H and R2 is methyl, it means urauchimycin B). The physical and chemical properties of Urauchimycin A are, molecular weight: 450; molecular formula: C22H30N2O8 [mass analysis: FAB-MAS 450 (M+1)+]; specific rotation: [α]26D=+46.7 (c=0.03 in methanol); solubility: soluble in chloroform, ethanol, ethyl acetate, acetone, slightly soluble in water and n-hexane; color reactions: positive to sulfuric acid; color of the substance: colorless. The compound of the formula is prepared by culturing a microorganism producing urauchimycnis A and B belonging to Streptomyces [Streptomyces sp. FERM-P-12392], to accumulate the substances in the culture and then collecting these antibiotics.
ADACHI KYOKO
NISHIJIMA MIYUKI
SANO HIROSHI
