Title:
Nucleic acid- Lipopolymer constituent
Document Type and Number:
Japanese Patent JP6027592
Kind Code:
B2
Abstract:
Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
Inventors:
Matal and Maged
Fewell, jason
Lewis, Danny, H.
Anwar, Kurseed
Fewell, jason
Lewis, Danny, H.
Anwar, Kurseed
Application Number:
JP2014212452A
Publication Date:
November 16, 2016
Filing Date:
October 17, 2014
Export Citation:
Assignee:
Agen, Inc.
International Classes:
A61K31/7088; A61K9/08; A61K9/19; A61K31/7105; A61K47/26; A61K47/34; A61K47/36; A61K47/38; A61K47/48; A61K48/00; C08K5/00; C08L33/10; C08L79/02; C08L89/00; C12N15/09; C12N15/113
Domestic Patent References:
| JP2007521247A | ||||
| JP2003524654A | ||||
| JP2004522809A | ||||
| JP2003519199A | ||||
| JP2004510829A |
Foreign References:
| WO1996021036A1 |
Attorney, Agent or Firm:
Asamura patent office