Title:
核酸切断剤
Document Type and Number:
Japanese Patent JP5156953
Kind Code:
B2
Abstract:
A nucleic acid cleaving agent having a cleaving activity specific to a desired cleavage site in a nucleic acid such as large DNA, which comprises (1) a nucleic acid cleaving moiety, and (2) at least two zinc finger proteins bound to the nucleic acid cleaving moiety, wherein at least one of the zinc finger proteins can specifically bind to a nucleotide sequence located upstream from the target cleavage site, and at least one of the remaining zinc finger proteins can specifically bind to a nucleotide sequence located downstream from the target cleavage site.
Inventors:
Takashi Sera
Application Number:
JP2008542543A
Publication Date:
March 06, 2013
Filing Date:
March 07, 2007
Export Citation:
Assignee:
Kyoto University
International Classes:
C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02
Domestic Patent References:
| JP2004519211A |
Other References:
Biochemistry,2002年,41,p.7074-81
Biochemical and Biophysical Research Communications,2005年,330(1),p.247-52
Accounts of Chemical Research,2006年,39(1),p.45-52
Biochemical and Biophysical Research Communications,2005年,330(1),p.247-52
Accounts of Chemical Research,2006年,39(1),p.45-52
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes
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