Ｃ型肝炎ウイルス由来のキメラ遺伝子を含む核酸

Japanese Patent JP5593220

B2

This invention provides infectious chimeric HCV particles that can be used for vaccines. This invention further provides a nucleic acid comprising a chimeric gene derived from the hepatitis C virus comprising regions each encoding Core protein, E1 protein, E2 protein and p7 protein derived from a hepatitis C virus strain other than JFH-1 strain; NS2 protein derived from JFH-1 strain or a hepatitis C virus strain other than JFH-1 strain, or a chimeric NS2 protein of NS2 protein derived from JFH-1 strain and NS2 protein derived from a hepatitis C virus strain other than JFH-1 strain; and NS3 protein, NS4A protein, NS4B protein, NS5A protein, and NS5B protein derived from JFH-1 strain in that order in 5' to 3' direction, wherein the 328th proline residue from the amino acid residue at N-terminus of the Core protein is substituted with an amino acid residue other than proline. This invention further provides chimeric HCV particles comprising such nucleic acid, and use of such HCV particles for vaccines.

JP2022133441	DIET CONTROLLED EXPRESSION OF NUCLEIC ACID ENCODING CAS9 NUCLEASE AND USES THEREOF
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JP4773338	Amplification and analysis of the entire genome and transcriptome library produced by the DNA polymerization process

Daisuke Akazawa
Wakita 隆字

JP2010509234A

September 17, 2014

April 24, 2009

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Toray Industries, Inc.
National Institute of Infectious Diseases length
Public utility foundation legal entity Tokyo medicine research institute

C12N15/09; A61K39/29; A61P31/14; C07K16/08; C12N5/10; C12N7/00; C12Q1/68; C12Q1/70

WO2007037428A1	2007-04-05
WO2006022422A1	2006-03-02

JPN6009024374; Ｊｏｕｒｎａｌ　ｏｆ　Ｖｉｒｏｌｏｇｙ，　２００７年１月，　ｖｏｌ．　８１，　ｎｏ．　２，　ｐ．　６２９-６３８
JPN6009024376; Ｈｅｐａｔｏｌｏｇｙ，　２００８年９月，　ｖｏｌ．　４８，　ｎｏ．　３，　ｐ．　７３２-７４０
JPN6009024378; 肝臓，　２００８年４月３０日，　ｖｏｌ．　４９，　ｓｕｐｐｌ．　１，　ｐ．　Ａ７０　（ＷＳ７-１０）

Yusuke Hiraki
Setsu Fujita

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