Title:
NUCLEIC ACID FIXING AGENT IN LIQUID
Document Type and Number:
Japanese Patent JP2018138012
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods of stably fixing nucleic acid molecules with variety of length on a substrate under mild conditions without requiring knowing the sequence of the nucleic acid molecule.SOLUTION: The present invention relates to a linker molecule which has on one end a nucleic acid base binding site having a nitrogen mustard structure specifically binding guanine that is a nucleic acid base and which has on another end a site binding a substrate, the linker molecule being configured to link these by a hydrophilic linker. By using the linker molecule, a nucleic acid molecule can be immobilized on a substrate via a linker molecule under mild conditions in an aqueous solution.SELECTED DRAWING: Figure 1
Inventors:
KURITA RYOJI
KOJIMA SUNAO
KURINOMARU TAKAAKI
KOJIMA SUNAO
KURINOMARU TAKAAKI
Application Number:
JP2017033930A
Publication Date:
September 06, 2018
Filing Date:
February 24, 2017
Export Citation:
Assignee:
AIST
International Classes:
C12N15/09; C07D339/04; C07H21/04