Title:
カプサイシン受容体およびカプサイシン受容体関連ポリペプチドをコードする核酸配列ならびにその使用
Document Type and Number:
Japanese Patent JP4444493
Kind Code:
B2
Abstract:
The present invention features vanilloid receptor polypeptides and vanilloid receptor-related polypeptides, specifically the capsaicin receptor subtypes VR1 and VR2 (VRRP-1), as well as the encoding polynucleotide sequences. In related aspects the invention features expression vectors and host cells comprising such polynucleotides. In other related aspects, the invention features transgenic animals having altered capsaicin receptor expression, due to, for example, the presence of an exogenous wild-type or modified capsaicin receptor-encoding polynucleotide sequence. The present invention also relates to antibodies that bind specifically to a capsaicin receptor polypeptide, and methods for producing these polypeptides. Further, the invention provides methods for using capsaicin receptor, including methods for screening candidate agents for activity as agonists or antagonists of capsaicin receptor activity, as well as assays to determine the amount of a capsaicin receptor-activating agent in a sample. In other related aspects, the invention provides methods for the use of the capsaicin receptor for the diagnosis and treatment of human disease and painful syndromes.
Inventors:
Julius David Jay.
Katerina Michael
Break anthony
Katerina Michael
Break anthony
Application Number:
JP2000509807A
Publication Date:
March 31, 2010
Filing Date:
August 20, 1998
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
A01K67/027; A61K38/00; C12N15/09; A61K39/395; A61P25/04; C07K14/705; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/566
Other References:
Nature,1997年10月23日,Vol.389,p.816-824
Attorney, Agent or Firm:
Hatsushi Shimizu