Title:
NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE
Document Type and Number:
Japanese Patent JP2015164958
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide materials and methods for conjugating water soluble polymers to proteins that improve the proteins' pharmacodynamic and/or pharmacokinetic properties while minimizing costs associated with various reagents and minimizing health risks to a patient recipient.SOLUTION: The present invention provides materials and methods for conjugating polymers to proteins that improve the proteins' pharmacodynamic and/or pharmacokinetic properties while minimizing costs associated with various reagents and minimizing health risks to a patient recipient. In various embodiments of the invention, alternative catalysts to substitute for aniline are provided.
Inventors:
SIEKMANN JUERGEN
STEFAN HAIDER
HANSPETER ROTTENSTEINER
ANDREAS IVENS
TURECEK PETER
OLIVER ZOECHLING
STEFAN HAIDER
HANSPETER ROTTENSTEINER
ANDREAS IVENS
TURECEK PETER
OLIVER ZOECHLING
Application Number:
JP2015118007A
Publication Date:
September 17, 2015
Filing Date:
June 11, 2015
Export Citation:
Assignee:
BAXTER INT
BAXTER HEALTHCARE SA
BAXTER HEALTHCARE SA
International Classes:
C07K1/113; A61K38/00; A61K38/21; A61K38/22; A61K38/27; A61K38/28; A61K38/43; A61K38/46; A61K38/48; A61K39/395; A61K47/48; A61P7/04; C07K14/47; C07K14/475; C07K14/52; C07K14/54; C07K14/555; C07K14/575; C07K14/705; C07K14/745; C07K14/755
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita