Title:
レトロウイルス逆転写酵素およびB型肝炎ウイルス(HBV)のDNAポリメラーゼのインヒビターを含む抗ウイルス剤などのヌクレオシドアナログ
Document Type and Number:
Japanese Patent JP3844654
Kind Code:
B2
Abstract:
A compound of the formula I wherein: nuc is the residue of a nucleoside analogue bonded through its single hydroxy group on the cyclic or acyclic saccharide moiety, R1 is hydroxy, amino or carboxy; optionally having esterified/amide bonded thereon a C4-C22 saturated or unsaturated, optionally substituted fatty acid or alcohol, or an aliphatic L-amino acid; R2 is the residue of an aliphatic L-amino acid; L1 is a trifunctional linker group; L2 is absent or a difunctional linker group; and pharmaceutically acceptable salts thereof.
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Inventors:
Xiao Xion Jou
Nils-Gunner Johansson
Horst wering
Nils-Gunner Johansson
Horst wering
Application Number:
JP2000509711A
Publication Date:
November 15, 2006
Filing Date:
August 14, 1998
Export Citation:
Assignee:
MEDIVIR AKTIEBOLAG
International Classes:
C07D473/18; A61K31/52; C07H19/16; A61K31/522; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7076; A61K31/708; A61P31/12; A61P31/16; A61P31/18; A61P43/00; C07D213/80; C07D213/85; C07D307/68; C07D473/00; C07D473/32; C07D473/34; C07D513/04; C07H17/08; C07H19/04; C07H19/173; C07B61/00; A61K31/00
Foreign References:
| WO1997027194A1 | ||||
| WO1994024134A1 | ||||
| EP0694547A2 | ||||
| US4957924 |
Attorney, Agent or Firm:
Aoyama Aoi
Kyousei Tamura
Yushiro Tsuboi
Kyousei Tamura
Yushiro Tsuboi