Title:
RNA依存性RNAウィルスポリメラーゼ阻害剤としてのヌクレオシド誘導体
Document Type and Number:
Japanese Patent JP2005530843
Kind Code:
A
Abstract:
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
Inventors:
Carroll, Stephen S
Olsen, David Bee
Deillet, Philip L
Bart, Barcelien
Dande, Prasad
Eldratop, Anne Bee
Olsen, David Bee
Deillet, Philip L
Bart, Barcelien
Dande, Prasad
Eldratop, Anne Bee
Application Number:
JP2004515870A
Publication Date:
October 13, 2005
Filing Date:
June 17, 2003
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
Isis PharmaceuticalsInc
Isis PharmaceuticalsInc
International Classes:
C07H19/067; A61K31/7056; A61K31/7068; A61K31/7072; A61K31/7076; A61K38/21; A61K45/00; A61P31/14; A61P43/00; C07H19/06; C07H19/10; C07H19/16; C07H19/167; C07H19/20; (IPC1-7): C07H19/067; A61K31/7056; A61K31/7068; A61K31/7072; A61K31/7076; A61K38/21; A61K45/00; A61P31/14; A61P43/00; C07H19/167
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura