Title:
RNA依存性RNAウィルスポリメラーゼ阻害薬としてのヌクレオシド誘導体
Document Type and Number:
Japanese Patent JP4931683
Kind Code:
B2
Abstract:
The present invention provides nucleoside derivatives (principally uracil, cytosine and uridine derivatives) which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.
Inventors:
Stephen S. Kyaroll
Robert El Rafumina
Dawn El Hall
Amy El Himelberger
Lawrence She Quo
Malcolm Matsukos
David Be Olsen
Karry A. Rutkowski
Giyoan E Tomasini
Hao Yun Ann
Barklishen Bert
Nee Lima Bert
Philip Dan Kukku
Anne Bee Eldratop
Chillards Jei Guinotsuso
Maria Purhaftsue
Tarza Pee Prakashiyu
Robert El Rafumina
Dawn El Hall
Amy El Himelberger
Lawrence She Quo
Malcolm Matsukos
David Be Olsen
Karry A. Rutkowski
Giyoan E Tomasini
Hao Yun Ann
Barklishen Bert
Nee Lima Bert
Philip Dan Kukku
Anne Bee Eldratop
Chillards Jei Guinotsuso
Maria Purhaftsue
Tarza Pee Prakashiyu
Application Number:
JP2007115345A
Publication Date:
May 16, 2012
Filing Date:
April 25, 2007
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
Isis Pharmaceuticals, Inc.
Isis Pharmaceuticals, Inc.
International Classes:
C07D487/04; A61K31/519; C07H19/06; A61K31/70; A61K31/7052; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7076; A61K31/708; A61K31/7105; A61K31/712; A61K38/21; A61K45/00; A61K45/06; A61P1/16; A61P31/14; A61P43/00; C07D473/00; C07D487/02; C07H19/00; C07H19/04; C07H19/048; C07H19/067; C07H19/09; C07H19/10; C07H19/14; C07H19/16; C07H19/167; C07H19/173; C07H19/19; C07H19/20; C07H; C12N
Foreign References:
| US6110901 | ||||
| WO1998055493A1 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Katsuma Osaki
Makoto Ono
Katsuma Osaki