Title:
MusashiによるNumbタンパク質発現抑制剤
Document Type and Number:
Japanese Patent JP3566941
Kind Code:
B2
Abstract:
An Numb protein expression inhibitor comprising, as active ingredient, Musashi protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi protein, or a gene encoding said polypeptide. By the present invention, a new function of Musashi protein has been elucidated. Described specifically, Musashi protein inhibits expression of Numb protein having a neuronal differentiation regulating function and potentiates the activity of the Notch signaling system, so that Musashi protein can be used as a therapeutic for various diseases of the central nervous system.
Inventors:
Takao Imai
Akihito Tokunaga
Satoshi Yoshida
Katsuhiko Mikoshiba
Masato Nakafuku
Hideyuki Okano
Akihito Tokunaga
Satoshi Yoshida
Katsuhiko Mikoshiba
Masato Nakafuku
Hideyuki Okano
Application Number:
JP2001164412A
Publication Date:
September 15, 2004
Filing Date:
May 31, 2001
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
C12N15/09; A61K38/00; A61K48/00; A61P25/00; A61P43/00; C07K14/47; C12N5/07; C12N5/0797; (IPC1-7): A61K38/00; A61K48/00; A61P25/00; A61P43/00; C12N5/06; C12N15/09
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation