Title:
O-アルキルマクロライドおよびO-アルキルアザリド誘導体、およびそれらを調製するためのレギオ選択的方法
Document Type and Number:
Japanese Patent JP2007502857
Kind Code:
A
Abstract:
The present disclosure relates to new 11-O-alkyl macrolides and azalides and pharmaceutically acceptable salts and solvates thereof, and to pharmaceutical compositions thereof. The disclosure also relates to a process for the preparation of 11-O-alkyl macrolides and azalides by regioselective 11-O-alkylation of macrolides and azalides having a vicinal diol system, using diazoalkanes in the presence of transition-metal halides or boric acid as catalysts. In another aspect, the disclosure relates to uses of the 11-O-alkyl macrolides and azalides as antibacterial agents or intermediates for the synthesis of other antibacterial agents.
Inventors:
Davo Kideme
Gorjana Lazarevski
Marco Derek
Marija Lerjak
Gorjana Lazarevski
Marco Derek
Marija Lerjak
Application Number:
JP2006530698A
Publication Date:
February 15, 2007
Filing Date:
May 27, 2004
Export Citation:
Assignee:
Privat-Istrajivaki Institudio Oh
International Classes:
C07D267/00; A61K31/395; A61K31/7048; A61K31/7052; A61P31/04; C07H17/00; C07H17/08; C07B61/00
Domestic Patent References:
| JP2002510701A | 2002-04-09 | |||
| JP2001520234A | 2001-10-30 | |||
| JPH05132497A | 1993-05-28 | |||
| JPS572298A | 1982-01-07 | |||
| JPH05239086A | 1993-09-17 | |||
| JP2004506664A | 2004-03-04 | |||
| JPS5896095A | 1983-06-07 |
Foreign References:
| WO2002015842A2 | 2002-02-28 |
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro