Title:
O-置換ヒドロキシアリール誘導体
Document Type and Number:
Japanese Patent JP4743382
Kind Code:
B2
Abstract:
A medicament having inhibitory activity against NF- kappa B activation which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in a main chain is 2 to 5 (said connecting group may be substituted), "A" represents an acyl group which may be substituted, (provided that unsubstituted acetyl group and unsubstituted acryloyl group are excluded,) or a C1 to C6 alkyl group which may be substituted, or A may bind to connecting group X to form a cyclic structure which may be substituted, "E" represents an aryl group which may be substituted or a heteroaryl group which may be substituted, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -X-E wherein each of X and E has the same meaning as that defined above.
Inventors:
Susumu Muto
Akiko Itai
Akiko Itai
Application Number:
JP2004510775A
Publication Date:
August 10, 2011
Filing Date:
June 05, 2003
Export Citation:
Assignee:
Pharmaceutical Molecular Design Laboratory Co., Ltd.
International Classes:
A61K31/167; A61K31/215; A61K31/223; A61K31/255; A61K31/265; A61K31/27; A61K31/36; A61K31/395; A61K31/40; A61K31/4035; A61K31/4409; A61K31/445; A61K31/455; A61K31/495; A61K31/536; A61K31/5375; A61K31/5377; A61K31/616; A61K31/661; A61K31/7034; A61K38/00; A61P29/00; A61P37/06; A61P43/00; C07C235/64; C07C271/22; C07C271/44; C07C271/54; C07C305/24; C07C307/06; C07C309/65; C07C309/66; C07C309/73; C07C321/28; C07D209/48; C07D211/62; C07D213/79; C07D213/80; C07D213/803; C07D265/16; C07D265/22; C07D265/24; C07D265/26; C07D267/00; C07D269/00; C07D273/00; C07D277/20; C07D277/46; C07D295/185; C07D295/20; C07D295/205; C07D309/10; C07D317/60; C07D333/16; C07F9/09; C07H15/203; C07K5/06; C07K5/062; C07K5/065; C07K5/068; C07K5/072
Domestic Patent References:
| JPS52110835A | 1977-09-17 | |||
| JPS5533484A | 1980-03-08 | |||
| JPS6299329A | 1987-05-08 | |||
| JP2000169479A | 2000-06-20 | |||
| JP4224566B2 | 2009-02-18 | |||
| JP4635130B2 | 2011-02-23 | |||
| JP4660674B2 | 2011-03-30 |
Foreign References:
| WO2001012588A1 | 2001-02-22 | |||
| WO2001000213A1 | 2001-01-04 | |||
| WO2001044217A1 | 2001-06-21 | |||
| WO1999065449A2 | 1999-12-23 | |||
| US3906023A | 1975-09-16 | |||
| FR1481713A | 1967-05-19 | |||
| WO2002076918A1 | 2002-10-03 |
Attorney, Agent or Firm:
Isshiki International Patent Service Corporation