NEW MATERIAL:The compound of formulaI(X is O or S; R is halogen, hydroxy, lower alkyl or lower alkoxy).
EXAMPLE: 6,6a,7,8,9,10,10a,11-octahydro-11-oxodibenzo[b,e]thiepin.
USE: Useful as a hypotensor or an intermediate of pharmaceuticals. Since the compound has two adjacent asymmetric carbon atoms (the C atoms at the 6a- and 10-positions), there are two kinds of trans-isomers and two kinds of cis- isomers.
PROCESS: The compound of formulaIcan be prepared in the form of a mixture of trans-isomer and cis-isomer, by cyclizing the compound of formula II (R1 is halogen, lower alkyl, or lower alkoxy) in the presence of a condensation agent such as polyphosphoric acid, in a solvent such as benzene. The mixture can be separated into the trans-isomer and the cis-isomer by column chromatography, etc. The starting compound of formula II is novel, and can be prepared according to the reaction formula.
| JPH0940662 | TRICYCLIC COMPOUND |
| JP2002527502 | INDUSTRIAL APPLICABILITY [Title of Invention] New compounds, preparation and use thereof |
| WO/1992/012133 | ARTHROPODICIDAL CARBOXANILIDES |
NAGAI YASUTAKA
KUROKAWA MIKIO
