PURPOSE: An oil emulsion that contains an indolacetic ester, thus showing anti- inflammatory and antipyretic effect with a long duration, high safety and reduced side-effects.
CONSTITUTION: An indolacetic ester of the formula (R is 1W18C alkyl, -CH2 COOR) is dissolved in a base for the oil emulsion and solution is combined with water, then homogenized to give the objective oil emulsion. The compound of the formula has high anti-inflammatory and analgesic activity, being widely used clinically. Since the compound is weaker in its activities than the compound of the formula where R is H (indomethacine) or that where R is -CH2COOH (acetmethacin), it has not been used, however, its use in the form of oil emulsion shows the same level of the pharmaceutical effect as of indolacetic acids, moreover, causes no dangerous side-effects such as troubles in digestive tracts, injection shocks or allergy.
YOKOYAMA KAZUMASA
OKAMOTO HIROYUKI
SUYAMA TADAKAZU
WADA YASUSHI
ISHIHAMA HIROSHI
WATANABE KOUICHIROU
KOWA CO
| JPS56167616A | 1981-12-23 | |||
| JPS52143218A | 1977-11-29 |
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