PURPOSE: To provide an ointment base containing propylene glycol, polyethylene glycol, gelation agent, glycerol and alkaline agent, capable of easily dissolving a hardly soluble drug, improving the releasability and absorbability of a drug and fully exhibiting its effect.
CONSTITUTION: The objective base can be produced by compounding (A) 5W30(wt)%, preferably 5W20% propylene glycol, (B) 5W50%, preferably 10W50% polyethylene glycol (having an average molecular weight of preferably 200W400), (C) 0.1W5% gelation agent such as carboxyvinyl polymer, CMC, sodium alginate, etc., (D) 10W40%, preferably 10W30% glycerol as moisture-retaining agent and (E) 0.1W3% alkaline agent (e.g. monoethanolamine, sodium hydroxide, etc.). Especially excellent effect can be attained in an ointment produced by compounding said ointment base with an adrenal cortical hormone as an anti- inflammatory agent in combination with dibucaine hydrochloride as a local anesthetic.
OKADA SHIGENOBU
HARA KENJI
JPS59122420A | 1984-07-14 |
Next Patent: USE OF AVARONE, AVAROL AND THEIR DERIVATIVES FOR CONTROLLINGADULT T-CELL LEUKEMIA/LYMPHADENITIS