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Title:
OINTMENT BASE
Document Type and Number:
Japanese Patent JPS62292716
Kind Code:
A
Abstract:

PURPOSE: To provide an ointment base containing propylene glycol, polyethylene glycol, gelation agent, glycerol and alkaline agent, capable of easily dissolving a hardly soluble drug, improving the releasability and absorbability of a drug and fully exhibiting its effect.

CONSTITUTION: The objective base can be produced by compounding (A) 5W30(wt)%, preferably 5W20% propylene glycol, (B) 5W50%, preferably 10W50% polyethylene glycol (having an average molecular weight of preferably 200W400), (C) 0.1W5% gelation agent such as carboxyvinyl polymer, CMC, sodium alginate, etc., (D) 10W40%, preferably 10W30% glycerol as moisture-retaining agent and (E) 0.1W3% alkaline agent (e.g. monoethanolamine, sodium hydroxide, etc.). Especially excellent effect can be attained in an ointment produced by compounding said ointment base with an adrenal cortical hormone as an anti- inflammatory agent in combination with dibucaine hydrochloride as a local anesthetic.


Inventors:
MURATA SHOICHI
OKADA SHIGENOBU
HARA KENJI
Application Number:
JP13556986A
Publication Date:
December 19, 1987
Filing Date:
June 11, 1986
Export Citation:
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Assignee:
KAO CORP
International Classes:
A61K9/06; A61K38/35; A61K47/00; (IPC1-7): A61K9/06; A61K47/00
Domestic Patent References:
JPS59122420A1984-07-14
Attorney, Agent or Firm:
Ariga Miyuki