Title:
再ミエリン化および脊髄損傷の治療のためのヒト胚性幹細胞に由来するオリゴデンドロサイト
Document Type and Number:
Japanese Patent JP5514756
Kind Code:
B2
Abstract:
This invention provides populations of neural cells bearing markers of glial cells, such as oligodendrocytes and their precursors. The populations are generated by differentiating pluripotent stem cells such as human embryonic stem cells under conditions that promote enrichment of cells with the desired phenotype or functional capability. Various combinations of differentiation factors and mitogens can be used to produce cell populations bearing markers of oligodendrocyte precursor cells. Upon further differentiation form complex processes characteristic of mature oligodendrocytes. The cells are capable of forming myelin sheaths, and can be used therapeutically improve function of the central nervous system.
Inventors:
Nistor Gabriel Eye.
Kiasted Hans S.
Kiasted Hans S.
Application Number:
JP2011047716A
Publication Date:
June 04, 2014
Filing Date:
March 04, 2011
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
C12N5/0735; C12Q1/02; A61P25/00; A61P25/28; A61P27/02; C12N5/079; C12N5/0797; A61K35/12
Foreign References:
| WO2001088104A1 |
Other References:
J. Neurosci. Res.,2000年,vol. 59,421-429
J. Neurosci. Res.,1997年,vol. 50,146-156
J. Neurosci. Res.,1997年,vol. 50,146-156
Attorney, Agent or Firm:
Naoto Uchida
Koji Okuhara
Koji Okuhara