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Title:
オリゴヌクレオチド非ウイルスデリバリーシステム
Document Type and Number:
Japanese Patent JP2010503640
Kind Code:
A
Abstract:
Low molecular weight low molecular weight chitosan oligomers were able to self-assemble siRNA into nanosized particles, provide protection against enzymatic degradation, and mediate gene silencing that is stable over a long period of time in vitro. The control of structural variables in formulating complexes of siRNA with low molecular weight chitosans provides an efficient alternative delivery system for siRNA in vitro and in vivo.

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Inventors:
Atterson, PA Arter Sven
Issa, Mohammed Marmoud
Strand, Sabina Pro Katsukoba
Balm, Gier Morten
Application Number:
JP2009527838A
Publication Date:
February 04, 2010
Filing Date:
September 14, 2007
Export Citation:
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Assignee:
FMc Biopolymer Ayes
International Classes:
A61K47/48; A61K31/7105; A61K47/36; A61K48/00; C12N15/87; C12N15/09
Domestic Patent References:
JP2005533016A2005-11-04
JP2005533078A2005-11-04
Other References:
JPN6012052387; ＧＡＯ　Ｓ　ＥＴ　ＡＬ: 'Ｔａｒｇｅｔｉｎｇ　ｄｅｌｉｖｅｒｙ　ｏｆ　ｏｌｉｇｏｎｕｃｌｅｏｔｉｄｅ　ａｎｄ　ｐｌａｓｍｉｄ　ＤＮＡ　ｔｏ　ｈｅｐａｔｏｃｙｔｅ　ｖｉａ　ｇａｌａｃｔｏｓｙｌａｔｅｄ　ｃｈｉｔｏｓａｎ　ｖｅｃｔ' ＥＵＲＯＰＥＡＮ　ＪＯＵＲＮＡＬ　ＯＦ　ＰＨＡＲＭＡＣＥＵＴＩＣＳ　ＡＮＤ　ＢＩＯＰＨＡＲＭＡＣＥＵＴＩＣＳ ｖｏｌ．　６０，　ｎｏ．　３, 200508, ｐａｇｅｓ　３２７-３３４
Attorney, Agent or Firm:
Takehiko Saito
Yasuyuki Hata



 
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