Title:
表皮水疱症治療のためのＣＯＬ７Ａ１エクソン７３とマッチするオリゴヌクレオチド
Document Type and Number:
Japanese Patent JP6929783
Kind Code:
B2
Abstract:
Antisense oligonucleotides capable of preventing or reducing exon 73 inclusion into the human COL7A1 mRNA are characterized in various ways: (a) the oligonucleotide's sequence includes at most two CpG sequences; (b) the oligonucleotide has a length of no more than 24 nucleotides; (c) the oligonucleotide is capable of annealing to the (SRp40/SC35 binding / ESE) element in exon 73. These oligonucleotides can usefully be oligoribonucleotides with modified internucleosidic linkages e.g. phosphorothioate linkages.
Inventors:
High Suma, Elizabeth, Maraine
Marco, Potman
Bumer, unter
Brinks Vera
Marco, Potman
Bumer, unter
Brinks Vera
Application Number:
JP2017547468A
Publication Date:
September 01, 2021
Filing Date:
March 11, 2016
Export Citation:
Assignee:
Wings Therapeutics, Incorporated
International Classes:
C12N15/113
Foreign References:
| WO2013053819A1 |
Other References:
J. Mol.Biol., 1994, 238, p.145-158
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Yasuhito Suzuki
Norio Omori
Yasuhito Suzuki