OLIGORIBONUCLEOTIDE AND METHOD OF USE THEREOF FOR TREATMENT OF FIBROTIC CONDITION AND OTHER DISEASES

Title:

OLIGORIBONUCLEOTIDE AND METHOD OF USE THEREOF FOR TREATMENT OF FIBROTIC CONDITION AND OTHER DISEASES

Document Type and Number:

Japanese Patent JP2011172579

Kind Code:

A

Abstract:

To provide an oligoribonucleotide and a method of using the same, for the treatment of fibrotic conditions and other diseases.

There are provided: a double-stranded compound, preferably an oligoribonucleotide (siRNA) compound, which down-regulates the expression of a human TGaseII gene at the post-transcriptional level; a pharmaceutical composition comprising a vector capable of expressing the oligoribonucleotide compound and a pharmaceutically acceptable carrier; a method of treating a patient suffering from a fibrotic disease such as pulmonary, kidney, and liver fibrosis or ocular scarring, including administering to the patient the pharmaceutical composition in a therapeutically effective dose; and also the treatment of fibrotic and other diseases by use of antibodies to TGaseII polypeptide.

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Inventors:

MOR ORNA
FEINSTEIN ELENA

Application Number:

JP2011083817A

Publication Date:

September 08, 2011

Filing Date:

April 05, 2011

Export Citation:

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Assignee:

QUARK PHARMACEUTICALS INC

International Classes:

C12N15/09; A61K48/00; C07H21/04; C07K14/705; C07K16/18; C07K16/40; C12N9/10; C12N15/113; C12Q1/68; A61K31/7088; A61P1/16; A61P11/00; A61P13/12; A61P27/02

Attorney, Agent or Firm:

Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu

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