Title:
Operated polypeptide in which operation duration increased and immunogenicity decreased
Document Type and Number:
Japanese Patent JP6040464
Kind Code:
B2
Abstract:
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including lipodystrophy, dyslipidemia, hyperlipidemia, overweight, obesity, hypothalamic amenorrhea, Alzheimer's disease, leptin deficiency, fatty liver disease or diabetes (including type I and type II). Additional diseases and disorders which can be treated by the compounds and methods described herein include nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), metabolic syndrome X and Huntington's Disease.
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Inventors:
Mary Ericsson
David Sea Ritzinger
Sumitra S. Gosh
Gigien Guo
Caroline Ekblad
Jonathan David Ross
David Sea Ritzinger
Sumitra S. Gosh
Gigien Guo
Caroline Ekblad
Jonathan David Ross
Application Number:
JP2014520216A
Publication Date:
December 07, 2016
Filing Date:
July 03, 2012
Export Citation:
Assignee:
Aegerion Pharmaceuticals, Inc.
International Classes:
C12N15/09; A61K38/22; A61P3/10; C07K1/04; C07K14/575; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Domestic Patent References:
| JP2010534486A |
Foreign References:
| WO2009100255A1 | ||||
| WO2010054699A1 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Fumio Inai
Manami Sasakura
Hiroshi Yamazaki
Kenji Tomita
Fumio Inai
Manami Sasakura