Title:
Opsin-binding ligand, composition, and usage
Document Type and Number:
Japanese Patent JP6322142
Kind Code:
B2
Abstract:
Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
Inventors:
Cork, tan
Berman, Judd
Garvey, David, Es.
Berman, Judd
Garvey, David, Es.
Application Number:
JP2014544720A
Publication Date:
May 09, 2018
Filing Date:
November 29, 2012
Export Citation:
Assignee:
Become Pharmaceuticals, Inc.
International Classes:
C07C211/52; A61K31/045; A61K31/085; A61K31/09; A61K31/10; A61K31/12; A61K31/136; A61K31/166; A61K31/277; A61K31/36; A61P27/02; A61P43/00; C07C33/38; C07C33/50; C07C43/215; C07C43/225; C07C43/23; C07C49/563; C07C49/813; C07C211/45; C07C217/84; C07C237/30; C07C255/54; C07C255/58; C07C323/09; C07D317/64; C07D317/66
Domestic Patent References:
| JP51133252A | ||||
| JP4226930A | ||||
| JP2010189371A | ||||
| JP63227563A | ||||
| JP59027873A | ||||
| JP50089541A |
Foreign References:
| WO2010150564A1 | ||||
| WO2010147653A1 | ||||
| WO2007037188A1 | ||||
| US4886916 | ||||
| US20110195979 | ||||
| WO2003063787A2 |
Other References:
Ohgane, Kenji; Dodo, Kosuke; Hashimoto, Yuichi,Structural development study of a novel pharmacological chaperone for folding-defective rhodopsin mutants responsible for retinitis pigmentosa,YAKUGAKU ZASSHI,2011年,131(3),325-334
Honda, Kiyoshi et al.,Highly Z Selective Synthesis of Functionalized Monoterpenoids via N-Ylide [2,3]Sigmatropic Rearrangement and Its Application to 13-cis-Retinol,CHEMISTRY LETTERS,1996年,(8),671-672
Synthesis, antimicrobial and antineoplastic activities for agelasine and agelasimine analogs with a β-cyclocitral derived substituent,Archiv der Pharmazie (Weinheim, Germany),2007年,340(12),625-634
Tetrahedron,2002年,58(34),6925-6930
Deng, Kai; Bensari, Ahlem; Cohen, Theodore,Cyclization by intramolecular carbolithiation of alkyl- and vinyllithiums prepared by reductive lithiation: Surprising stereochemistry in the lithium oxyanion accelerated cyclization,Journal of the American Chemical Society,2002年,124(41),12106-12107
Beckwith, Athelstan L. J.; Palacios, Sara M.,SRN1 reactions of nucleophiles with radical clocks: rate constants for some radical-nucleophile reactions,Journal of Physical Organic Chemistry,1991年,4(7),404-412
Fehr, Charles; Galindo, Jose,42. Syntheses of the enantiomers of γ-cyclogeranic acid, γ-cyclocitral, and γ-damascone: enantioselective protonation of enolates,Helvetica Chimica Acta,1995年,78(3),539-552
Matsumoto, Takashi; Ohmura, Taishi; Usui, Shuji,The revised structure of dispermol and total synthesis of maytenoquinone, dispermol, and dispermone,Bulletin of the Chemical Society of Japan,1979年,52(7),1957-1963
Liebeskind, Lanny S.; Chidambaram, Ramakrishnan; Nimkar, Sanjay; Liotta, Dennis,A synthesis of the abietane diterpenoid quinone (±)-royleanone via maleoylcobalt technology,Tetrahedron Letters,1990年,31(26),3723-3726
Burnell, Robert H.; Jean, Michel; Poirier, Donald,Synthesis of taxodione,Canadian Journal of Chemistry,1987年,65(4),775-781
Shive, Billie; Horeczy, Joe; Wash, George; Lochte, H. L.,"Trans"-2,2,6-Trimethylcyclohexanecarboxylic acid: a second solid naphthenic acid from California petroleum,Journal of the American Chemical Society,1942年,64,385-391
Edwards, O. E.; Lesage, M.,The deamination of alicyclic α-aminoketones,Canadian Journal of Chemistry ,1963年,41,1592-1605
Davis, Brian R.; Hinds, Mark G.; Johnson, Stephen J.,Diterpene synthesis. III. Acid-catalysed cyclization of methoxy-phenylethyltrimethyl-cyclohexanols, -cyclohexenols and -cyclohexenones,Australian Journal of Chemistry,1985年,38(12),1815-25
Honda, Kiyoshi et al.,Highly Z Selective Synthesis of Functionalized Monoterpenoids via N-Ylide [2,3]Sigmatropic Rearrangement and Its Application to 13-cis-Retinol,CHEMISTRY LETTERS,1996年,(8),671-672
Synthesis, antimicrobial and antineoplastic activities for agelasine and agelasimine analogs with a β-cyclocitral derived substituent,Archiv der Pharmazie (Weinheim, Germany),2007年,340(12),625-634
Tetrahedron,2002年,58(34),6925-6930
Deng, Kai; Bensari, Ahlem; Cohen, Theodore,Cyclization by intramolecular carbolithiation of alkyl- and vinyllithiums prepared by reductive lithiation: Surprising stereochemistry in the lithium oxyanion accelerated cyclization,Journal of the American Chemical Society,2002年,124(41),12106-12107
Beckwith, Athelstan L. J.; Palacios, Sara M.,SRN1 reactions of nucleophiles with radical clocks: rate constants for some radical-nucleophile reactions,Journal of Physical Organic Chemistry,1991年,4(7),404-412
Fehr, Charles; Galindo, Jose,42. Syntheses of the enantiomers of γ-cyclogeranic acid, γ-cyclocitral, and γ-damascone: enantioselective protonation of enolates,Helvetica Chimica Acta,1995年,78(3),539-552
Matsumoto, Takashi; Ohmura, Taishi; Usui, Shuji,The revised structure of dispermol and total synthesis of maytenoquinone, dispermol, and dispermone,Bulletin of the Chemical Society of Japan,1979年,52(7),1957-1963
Liebeskind, Lanny S.; Chidambaram, Ramakrishnan; Nimkar, Sanjay; Liotta, Dennis,A synthesis of the abietane diterpenoid quinone (±)-royleanone via maleoylcobalt technology,Tetrahedron Letters,1990年,31(26),3723-3726
Burnell, Robert H.; Jean, Michel; Poirier, Donald,Synthesis of taxodione,Canadian Journal of Chemistry,1987年,65(4),775-781
Shive, Billie; Horeczy, Joe; Wash, George; Lochte, H. L.,"Trans"-2,2,6-Trimethylcyclohexanecarboxylic acid: a second solid naphthenic acid from California petroleum,Journal of the American Chemical Society,1942年,64,385-391
Edwards, O. E.; Lesage, M.,The deamination of alicyclic α-aminoketones,Canadian Journal of Chemistry ,1963年,41,1592-1605
Davis, Brian R.; Hinds, Mark G.; Johnson, Stephen J.,Diterpene synthesis. III. Acid-catalysed cyclization of methoxy-phenylethyltrimethyl-cyclohexanols, -cyclohexenols and -cyclohexenones,Australian Journal of Chemistry,1985年,38(12),1815-25
Attorney, Agent or Firm:
Toshikazu Kaji
Hiroyuki Niwa
Eiko Nakamura
Nishio Mira
Hiroyuki Niwa
Eiko Nakamura
Nishio Mira
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