Title:
OPTICAL RESOLUTION OF (+-)-1-PHENYLETHYLAMINE
Document Type and Number:
Japanese Patent JPS5626848
Kind Code:
A
Abstract:
PURPOSE: To carry out optical resolution of the titled compound, an optical resolving agent for a racemic acid and an asymmetric sourse for asymmetric synthesis in high, yield by using an optically active mandelic acid as an optical resolving agent.
CONSTITUTION: Optical resolution of (±)-1-phenylethylamine is cariied out by using an optically active mandelic acid, where a soluble (±)-1-phenylethyl-amine salt may be present. Water is preferable as a solvent. The above treatment forms a diastereomeric salt, which is optically resolved by the deference in solubility thereof. The salt thus obtained is treated with a base to give (+)- or (-)-1-phenylethylamine, which is then treated with an acid to recover (-)- or (+)-mandelic acid.
Inventors:
KAMIYA NAOMI
YOSHIKAWA MASAHIDE
TOBIYAMA TADASHI
NOHIRA HIROYUKI
FUJIMURA RIEKO
YOSHIKAWA MASAHIDE
TOBIYAMA TADASHI
NOHIRA HIROYUKI
FUJIMURA RIEKO
Application Number:
JP10226179A
Publication Date:
March 16, 1981
Filing Date:
August 13, 1979
Export Citation:
Assignee:
YAMAKAWA CHEMICAL IND
International Classes:
C07B57/00; C07B31/00; C07C67/00; C07C209/00; C07C209/88; C07C211/27; (IPC1-7): C07B19/00; C07C85/26; C07C87/28
Domestic Patent References:
| JPS4718737U | 1972-11-01 |