PURPOSE: To enable to partially optically resolve various carboxylic acids to provide the optically active carboxylic acids in high selectivities by employing an optically active porphyrin derivative or a metal salt thereof as a transporting carrier in a liquid membrane method.
CONSTITUTION: When a racemic compound having a carboxylic acid group such as an amino acid is subjected to an optical resolution process, the optical resolution is performed by a liquid membrane method employing an optically active porphyrin N-substituted product organic acid complex metal complex of formula I or II (R1-12 is H, ≤20C monovalent hydrocarbon group or carboxylic acid derivative wherein R2 is ≤10C monovalent hydrocarbon group; the groups of at least one pair selected from the pairs of R1 and R2, R3 and R12, R4 and R11, R3 and R10, R6 and R9, and R7 and R8 is different from each other; M is Zn, Mn, Fe, Co, etc.; X is halogen, etc.). The method permits to optically resolve various carboxylic acids partially and the modification of the substituent of the porphyrin provides the objective optically active carboxylic acid in a high asymmetric selectivity. The method is profitable.
AIDA TAKUZO
KUBO HIDEO
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