OPTICAL RESOLUTION WHICH OBTAINS OPTICAL ACTIVITY (R)-1-(4-FLUORO PHENYL)ETHYLAMINE

Title:

OPTICAL RESOLUTION WHICH OBTAINS OPTICAL ACTIVITY (R)-1-(4-FLUORO PHENYL)ETHYLAMINE

Document Type and Number:

Japanese Patent JP2011231071

Kind Code:

A

Abstract:

To provide an industrial optical resolution which obtains optical activity (R)-1-(4-fluoro phenyl)ethylamine.

The optical resolution is carried out using natural type L-(-)-malic acid as a resolving agent, thereby optical activity (R)-1-(4-fluoro phenyl)ethylamine can be obtained. Further, the optical resolution is combined with an optical resolution which uses natural type L-(+)-tartaric acid for a resolving agent to obtain optical activity (S)-1-(4-fluoro phenyl)ethylamine, thereby a resolution efficiency of optical activity (R)-1-(4-fluoro phenyl)ethylamine can be improved. Moreover, in the optical resolution, a salt which consists of optical activity (R)-1-(4-fluoro phenyl)ethylamine and natural type L-(-)-malic acid and becomes a key diastereomer salt has been found out as a novel compound.

Inventors:

ISHII AKIHISA
UEDA KOJI
KATO MISUGI
YASUMOTO MANABU
OTSUKA TAKASHI
TSURUTA HIDEYUKI

Application Number:

JP2010104451A

Publication Date:

November 17, 2011

Filing Date:

April 28, 2010

Export Citation:

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Assignee:

CENTRAL GLASS CO LTD

International Classes:

C07C209/88; C07C59/245; C07C211/29; C07B57/00

Domestic Patent References:

JPH09278718A	1997-10-28
JPS5859948A	1983-04-09
JPS63119465A	1988-05-24
JP2003511377A	2003-03-25
JP2002003453A	2002-01-09

Foreign References:

CN1760176A

2006-04-19

Other References:

JPN6014006916; Ａｃｔａ　Ｃｒｙｓｔ．Ｃ６０, 2004, ６１７-６２２

Attorney, Agent or Firm:

Makoto Koide

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