To inexpensively obtain the subject compound useful as a synthetic intermediate for an agrochemical and medicine in good yield by hydrolyzing a specific hydroxamic acid derivative while keeping the configuration thereof.
The objective compound of formula II such as (S)-1-(3- trifluoromethylphenyl)ethoxyamine is obtained by hydrolyzing an optically active hydroximic acid derivative of formula I [Ar is an aryl or the like; X is H or the like; (n) is 1-3; R is a 1-4C alkyl or the like], [e.g. (R)-O-{1-(3- trifluoromethylphenyl)ethyl}-acetohydroxamate] while keeping the configuration by using an acid or a base such as potassium hydroxide of 1-5 times equivalent to the compound of formula I in an inert solvent such as ethanol at 20-120°C. The compound of formula I is obtained by reacting an optically active 1- arylethyl halide derivative of formula III (L is a halogen) with a hydroxamic acid of formula IV.
Ono, Fumihiko
Tanaka, Takeshi
Katsurada, Manabu
