NEW MATERIAL:An optically active compound of formula I (A is formula II, III; R1 is H, -COR7; R2, R3 are lower alkoxy; R4, R5 are both H or one of them is H, the other is -COR7; R6 is H, hydroxyl; R7 is lower alkyl, lower halogenoalkyl; the configuration in the 9-position is same as in the 2-position of l-2- acetyl-2-acetamino-1, 2, 3, 4-tetrahydro-5, 8-dimethoxynaphthalene; the configurations of the C-O bond in the 7-position and the C-N bond in the 9-position are cis except when R6 in formula II and III are H).
EXAMPLE: l-9-Acetyl-9-acetamino-6, 11-dihydroxy-7, 8, 9, 10-tetrahydro-5, 12-naphthacenedione.
USE: Antibacterial, carcinostatic agent.
PREPARATION: The reaction of an optically active compound of formula IV with phthalic anhydride is carried out in the presence of a Lewis acid to give a compound of formula I where A is formula II; R1, R6 are H, R2 and R3 forms oxo, one of R4 and R5 is H and the other is -COR7.
OOHASHI NAOHITO
MURAMATSU MICHIHISA
| JPS5829750A | 1983-02-22 |