Title:
OPTICALLY ACTIVE BETA-LACTAM
Document Type and Number:
Japanese Patent JPS6348274
Kind Code:
A
Abstract:
NEW MATERIAL:An optically active β-lactam compound of formula I or formula II [R1 is alkyl or aralkyl; R2 is COOR5 (R5 is alkyl or aralkyl) or SO2R6 (R6 is alkyl or aryl); R3 and R4 are H, alkyl, cycloalkyl, aryl or aralkyl or R3 and R4 together form an alkylene; Z is H or amino-protecting group].
EXAMPLE: (3R, 4R)-4-[(1S)-1,2-dihydroxy-1,2-o-isopropylidene]ethyl-3-(N-methoxy carbonyl-N-methyl)amino-1-(4-methoxy)phenyl-2-azetidinone.
USE: A production intermediate for a novel 6-disubstituted aminocarbapenem antibiotic substance.
PREPARATION: The compound of formula I or formula II can be produced e.g. by reacting a reactive derivative of glycine derivative of formula III with a compound of formula IV or formula V.
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Inventors:
YOSHIOKA TAKEO
FUKAGAWA YASUO
ISHIKURA TOMOYUKI
FUKAGAWA YASUO
ISHIKURA TOMOYUKI
Application Number:
JP19119786A
Publication Date:
February 29, 1988
Filing Date:
August 16, 1986
Export Citation:
Assignee:
SANRAKU INC
International Classes:
C07D205/085; C07D205/00; C07D205/08; C07D317/00; C07D405/04; C07D477/00; C07D487/04; (IPC1-7): C07D205/00; C07D205/08; C07D317/00; C07D405/04; C07D487/04
Attorney, Agent or Firm:
Heiyoshi Odashima