Title:
光学活性なビス(アルキニルホスフィノ)エタンーボラン誘導体及びその製造方法
Document Type and Number:
Japanese Patent JP5032161
Kind Code:
B2
Abstract:
An optically-active bis(alkynylphosphino)ethane-borane derivative represented by formula (1): wherein R1 and R2, which may be the same or different, each represent an alkyl group, a phenyl group, an alkylsilyl group or a hydrogen atom; R3 represents a branched alkyl group, an alicyclic hydrocarbon group or an aromatic hydrocarbon group; and the asterisk * indicates an optically-active site. The derivative (1) is prepared by bromination of, e.g., an (S)-t-butylmethylphosphine-borane, reaction with an alkynyl lithium, deprotonation, followed by oxidative coupling. Deprotection of the derivative (1) by deboranation gives an optically-active bis(alkynylphosphino)ethane derivative useful as a ligand providing an asymmetric catalyst for catalytic asymmetric synthesis. The asymmetric catalyst having the ligand exhibits high selectivity and catalyst activity.
Inventors:
Tsuneo Imamoto
Kazuhiro Yoshida
Yoichi Saito
Koide Aya
Kazuhiro Yoshida
Yoichi Saito
Koide Aya
Application Number:
JP2007060784A
Publication Date:
September 26, 2012
Filing Date:
March 09, 2007
Export Citation:
Assignee:
Nippon Chemical Industry Co., Ltd.
National University Corporation Chiba University
National University Corporation Chiba University
International Classes:
C07F19/00; B01J31/24; C07B53/00; C07F5/02; C07F9/54
Domestic Patent References:
| JP2000136193A | ||||
| JP1180179A |
Other References:
日本化学会第87春季年会(2007),日本,社団法人日本化学会,2007年 3月12日,講演予稿集II,1070頁,2 D8-16
Journal of the American Chemical Society,米国,2006年,Vol. 128,9336-9337
Journal of the American Chemical Society,米国,2006年,Vol. 128,9336-9337
Attorney, Agent or Firm:
Osamu Hatori
Yoshiyuki Matsushima
Yoshiyuki Matsushima