NEW MATERIAL:A compound expressed by formula I [R1 is H, lower alkyl or lower alkoxy; R2 and R3 are H, halogen, lower alkyl, etc.; A is -(CH2)m- (m is 0W5)].
EXAMPLE: cis(+)-2-Methyl-1,2,3,4-tetrahydro-1-naphthoic acid.
USE: An intermediate for medicine and agricultural chemical and plant-growth regulator.
PREPARATION: An olefin derivative expressed by formula II is subjected to asymmetric reduction with hydrogen in the presence of a metallic catalyst modified with an optically active metallocenylphosphine derivative expressed by formula III [R4 and R5 are lower alkyl or 5W8C hetero ring; R6 and R7 are H or lower alkyl; X is methylene, O or NR8 (R8 is H, etc.); Z is alkylene or C=0, etc.; Y is OR9 (R9 is H or lower alkyl); M is Fe, Ru, etc.; n is 0 or 1] to provide the compound expressed by formula I.
HAYASHI TAMIO
KAWAMURA NORIO
TAKEMOTO KAZUKI
IZUMI KAZUO
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