Title:
OPTICALLY ACTIVE DERIVATIVE OF MERCAPTOISOBUTYRIC ACID
Document Type and Number:
Japanese Patent JPS5538386
Kind Code:
A
Abstract:
Optically active compounds of formula in which R is either a H3C-, (CH3)3C-, (CH3)3CO-, C6H5CH2O-, C6H5-, o-NO2C6H4-, p-NO2C6H4- or a p-CH3C6H4-group, or salts or lower alkyl esters thereof. The compounds are prepared by the following sequence of reaction steps: (a) there is started from a racemic mixture of a compound according to said formula in which R=a C6H5 group, (b) cinchonidine, D(-)-2-aminobutanol-1 or a derivative thereof is added to this compound as resolving agent, (c) the D(-)-salt of the resolving agent formed is crystallized out and isolated, (d) if necessary, this salt is further purified of the L-isomer by recrystallization, (e) the pure D(-)-salt is hydrolysed in order to remove the resolving agent, (f) the D(-)-S-benzoyl- beta -mercaptoisobutyric acid thus liberated is won and, if necessary, purified, and (g) if desired, the C6H5 group is replaced, in a way known per se, by one of the other possible groups indicated above for R.
Inventors:
YOANNESU PAURUSU MARII HOUBIYA
Application Number:
JP11468379A
Publication Date:
March 17, 1980
Filing Date:
September 06, 1979
Export Citation:
Assignee:
OCE ANDENO BV
International Classes:
C07C327/32; C07C67/00; C07C325/00; C07C327/06; C07C327/20; C07C327/22; C07C329/06; (IPC1-7): C07C153/01
Domestic Patent References:
| JPS54151912A | 1979-11-29 |
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