Title:
OPTICALLY ACTIVE DICARBOXYLIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP2011184393
Kind Code:
A
Abstract:
To provide a method for synthesizing an optically active dicarboxylic acid derivative.
The method for synthesizing an optically active dicarboxylic acid derivative comprises allowing an α, β-unsaturated carbonyl compound and a compound formable of an enolate to react with each other in the presence of a catalyst constituted of a pyridine derivative having 4-phenyloxazolin-2-yl groups on the 2-position and the 6-position thereof respectively and an alkaline earth metal salt such as calcium ethoxide, whereby an optically active dicarboxylic acid derivative such as a 2-alkylpentane dicarboxylic acid derivative can efficiently be synthesized at a high yield with high enantioselectivity.
Inventors:
KOBAYASHI OSAMU
YAMASHITA TAKAHIRO
THOMAS POISSON
YAMASHITA TAKAHIRO
THOMAS POISSON
Application Number:
JP2010053300A
Publication Date:
September 22, 2011
Filing Date:
March 10, 2010
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY
International Classes:
C07C51/06; B01J31/26; C07C55/02; C07D263/20; C07B53/00; C07B61/00
Other References:
JPN6012054401; Ｊｏｕｒｎａｌ ｏｆ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１３０, 2008, ｐ．２４３０-２４３１
JPN6012054402; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４７, 2006, ｐ．１２９１-１２９３
JPN6012054404; Ｔｅｔｒａｈｅｄｒｏｎ： Ａｓｙｍｍｅｔｒｙ Ｖｏｌ．９, 1998, ｐ．１-４５
JPN6012054402; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４７, 2006, ｐ．１２９１-１２９３
JPN6012054404; Ｔｅｔｒａｈｅｄｒｏｎ： Ａｓｙｍｍｅｔｒｙ Ｖｏｌ．９, 1998, ｐ．１-４５
Attorney, Agent or Firm:
Katsumi Utaka