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Title:
OPTICALLY ACTIVE N-CARBOALKYLATED AMINO ALCOHOL
Document Type and Number:
Japanese Patent JPS63258448
Kind Code:
A
Abstract:

NEW MATERIAL:The compound of formula I, II, III or IV (Ph is phenyl; R1 is 1W4C alkyl; R2 is H, 1W10C alkyl or 6W10C aryl; X is -O- or -S-; Z is H, 1W10C alkyl or metal).

EXAMPLE: (1R,2S)-2-ethoxycarbonylmethylamino-1-phenyl-propanol.

USE: Useful as a reaction reagent for asymmetric synthesis, especially as a separation agent for optical resolution of a recemic compound.

PREPARATION: The compound of formula I, II, III or IV can be produced by alkylating an optically active isomer of erythro-2-amino-1-phenyl-1-propanol (norephedrine) with a carbomethylation agent and converting the ester part to a metal salt with sodium hydroxide, etc.


Inventors:
SAIGO KAZUHIKO
YUKI YOICHI
KIMOTO HIROKI
NISHIDA TORU
HASEGAWA MASAKI
Application Number:
JP1987000092745
Publication Date:
October 25, 1988
Filing Date:
April 15, 1987
Export Citation:
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Assignee:
SAIGO KAZUHIKO
International Classes:
C07C327/04; C07C67/00; C07C227/00; C07C227/08; C07C229/14; C07C229/36; C07C325/00; C07C327/06; C07C327/22; (IPC1-7): C07C99/00; C07C101/12; C07C101/18; C07C101/28; C07C153/01; C07C153/09; C07C153/11