Title:
OPTICALLY ACTIVE PYRROLIDINE DERIVATIVE AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JPH04198164
Kind Code:
A
Abstract:
NEW MATERIAL:The optically active compound of formula I [R1 is benzyl; R2 is 1-6C alkyl; R3 is 1-6C alkyl, benzyl or allyl; R4 is H, 1-6C alkyl (substituted with protected OH), vinyl, (substituted) phenyl, (substituted) benzyl or heterocyclic group containing 1-4 N or O atoms; R5 is H or methyl].
EXAMPLE: (2S,5R)-1-benzyl-5-[2-hydroxy-2-methyl-1-(t-butoxycarbonyl) propyl]pyrrolidine-2-carboxylic acid isopropyl ester.
USE: A synthetic intermediate for carbapenems (β-lactam antibiotic substance) having excellent antibacterial activity.
PREPARATION: The compound of formula I can be produced by reacting a compound of formula II with a base and a carbonyl compound of formula III.
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Inventors:
INAYAMA TAKASHI
SAKURAI KUNIYA
IZAWA HIROYUKI
IZAWA KUNISUKE
OTA TOMIHISA
NOZOE SHIGEO
SAKURAI KUNIYA
IZAWA HIROYUKI
IZAWA KUNISUKE
OTA TOMIHISA
NOZOE SHIGEO
Application Number:
JP32768190A
Publication Date:
July 17, 1992
Filing Date:
November 28, 1990
Export Citation:
Assignee:
AJINOMOTO KK
International Classes:
C07D477/00; C07D207/16; C07D401/06; C07D405/06; (IPC1-7): C07D207/16; C07D401/06; C07D405/06; C07D477/00