Title:
OPTICALLY-BASED STIMULATION OF TARGET CELLS AND MODIFICATIONS THERETO
Document Type and Number:
Japanese Patent JP2015214558
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide optically-based stimulation of target cells and modifications thereto, and particularly, various methods and devices of using light to stimulate target cells in vitro.SOLUTION: The present invention includes step-function opsins (SFOs) in which at least one of C128 and D156 is substituted, a light-activated molecule as one example, a modification to a location near the all-trans retinal Schiff base thereof, i.e., extending the duration of an open state, and a method for ion channels or pumps or for controlling currents in a cell (e.g., in environments in vivo and in vitro).
Inventors:
KARL DEISSEROTH
OFER YIZHAR
LISA GUNAYDIN
PETER HEGEMANN
ANDRE BERNDT
OFER YIZHAR
LISA GUNAYDIN
PETER HEGEMANN
ANDRE BERNDT
Application Number:
JP2015126039A
Publication Date:
December 03, 2015
Filing Date:
June 23, 2015
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR
International Classes:
C07K14/215
Foreign References:
| WO2007024391A2 | 2007-03-01 |
Other References:
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 16, JPN6014015788, 2004, pages 16403 - 16409
Attorney, Agent or Firm:
Naoto Uchida