Title:
配列操作のための最適化されたＣＲＩＳＰＲ－Ｃａｓ二重ニッカーゼ系、方法および組成物
Document Type and Number:
Japanese Patent JP7083364
Kind Code:
B2
Abstract:
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.
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Inventors:
Chang Feng
Supertric
Rinche Yu
Run Faye
Supertric
Rinche Yu
Run Faye
Application Number:
JP2020025947A
Publication Date:
June 10, 2022
Filing Date:
February 19, 2020
Export Citation:
Assignee:
The Broad Institute Incorporated
Massachusetts Institute of Technology
President and Fellow's of Harvard College
Massachusetts Institute of Technology
President and Fellow's of Harvard College
International Classes:
C12N15/09; C12N9/16; C12N15/113; C12N15/55; C12N15/63; C12N15/864
Domestic Patent References:
| JP2013518602A | ||||
| JP2007501626A | ||||
| JP2012529287A |
Foreign References:
| WO2013052681A1 | ||||
| WO2014197568A2 |
Other References:
CONG, Le et al.,"Multiplex genome engineering using CRISPR/Cas systems",Science,2013年,Vol. 339,pp. 819-823, Supplementary Materials,Published online: 2013 Jan 3
MALI, Prashant et al.,"RNA-guided human genome engineering via Cas9",Science,2013年,Vol. 339,pp. 823-826, Supplementary Materials,Published online: 2013 Jan 3
JINEK, Martin et al.,"RNA-programmed genome editing in human cells",Elife,2013年01月29日,Vol. 2; e00471,pp. 1-9
JIANG, Wenyan et al.,"RNA-guided editing of bacterial genomes using CRISPR-Cas systems",Nat. Biotechnol.,2013年01月29日,Vol. 31,pp. 233-239
URNOV, Fyodor D. et al.,"Genome editing with engineered zinc finger nucleases",Nat. Rev. Genet.,2010年,Vol. 11,pp. 636-646
MALI, Prashant et al.,"RNA-guided human genome engineering via Cas9",Science,2013年,Vol. 339,pp. 823-826, Supplementary Materials,Published online: 2013 Jan 3
JINEK, Martin et al.,"RNA-programmed genome editing in human cells",Elife,2013年01月29日,Vol. 2; e00471,pp. 1-9
JIANG, Wenyan et al.,"RNA-guided editing of bacterial genomes using CRISPR-Cas systems",Nat. Biotechnol.,2013年01月29日,Vol. 31,pp. 233-239
URNOV, Fyodor D. et al.,"Genome editing with engineered zinc finger nucleases",Nat. Rev. Genet.,2010年,Vol. 11,pp. 636-646
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes
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