Title:
酵母におけるHPV58L1の最適化発現
Document Type and Number:
Japanese Patent JP4912885
Kind Code:
B2
Abstract:
Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.
Inventors:
Brian, Janine Tay
Brown Law, Michelle Kay
Schulz, Lauren Day
One, Shin-Min
Katsen Woo, Janssen
Brown Law, Michelle Kay
Schulz, Lauren Day
One, Shin-Min
Katsen Woo, Janssen
Application Number:
JP2006539751A
Publication Date:
April 11, 2012
Filing Date:
November 10, 2004
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C12N15/09; A61K39/12; A61K48/00; C07K14/025; C12N1/19; C12N15/81; C12P21/02
Domestic Patent References:
| JP2003512031A | 2003-04-02 | |||
| JP2003511010A | 2003-03-25 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Katsuma Osaki
Katsuma Osaki