Title:
抗ＶＥＧＦ抗体の最適化変異体
Document Type and Number:
Japanese Patent JP6959912
Kind Code:
B2
Abstract:
The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
Inventors:
Koenig, patrick
Lee, Jin Wei Vivian
Rajagopal, Calcican
Family, amin
Who, Jermain
Lee, Jin Wei Vivian
Rajagopal, Calcican
Family, amin
Who, Jermain
Application Number:
JP2018515130A
Publication Date:
November 05, 2021
Filing Date:
September 23, 2016
Export Citation:
Assignee:
Genentech, Incorporated
International Classes:
C12N15/13; A61K39/395; A61P3/10; A61P9/10; A61P19/10; A61P27/02; A61P27/06; A61P35/00; C07K16/22; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/62; C12N15/63; C12P21/08
Domestic Patent References:
| JP2007526756A | ||||
| JP2007501011A | ||||
| JP2006517399A | ||||
| JP2013508308A |
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation