ORAL ADMINISTRATION OF PNEUMOCOCCUS ANTIGEN

Title:

ORAL ADMINISTRATION OF PNEUMOCOCCUS ANTIGEN

Document Type and Number:

Japanese Patent JPH11240844

Kind Code:

A

Abstract:

To protect a host from infection with pneumococcus such as innidiative infection and systemic infection by orally administering pneumococcus surface protein A (PspA) or a fragment of the PspA having a defensive induced epitope to the host to induce the immunological response.

An effective amount of PspA [killed whole Streptococcus pneumoniae, a lysate of the whole Streptococcus pneumoniae, the purified PspA or the like] and/or an immunogenic fragment including at least one epitope is orally or perorally administered preferably to a digestive canal (stomach, intestine or the like). The oral administration can protect the host not only from lung infection but also from infection caused by the lung infection.

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Inventors:

BRILES DAVID E
MCDANIEL LARRY S
YAMAMOTO MASAFUMI
KIYONO HIROSHI

Application Number:

JP1122898A

Publication Date:

September 07, 1999

Filing Date:

January 23, 1998

Export Citation:

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Assignee:

UAB RESEARCH FOUNDATION (US)

International Classes:

A61K39/00; A61K31/00; A61K35/74; A61K39/02; A61K39/09; A61K39/39; A61P31/04; A61P37/00; A61P37/02; C12N1/20; C12N15/00; A61K; (IPC1-7): A61K39/00; A61K35/74; A61K39/09; A61K39/39

Attorney, Agent or Firm:

Seiji Yanagida (1 person outside)

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