Title:
シクロオキシゲナーゼ-2阻害剤の経口速溶性投薬形態
Document Type and Number:
Japanese Patent JP2004506681
Kind Code:
A
Abstract:
A process is provided for preparing an oral fast-melt composition of a selective cyclooxygenase-2 inhibitory drug comprising (a) a step of wet granulating the selective cyclooxygenase-2 inhibitory drug together with a binding agent selected from gums, polypeptides, natural and modified starches, cellulosic materials, alginic acid and salts thereof, polyethylene glycol, polyvinylpyrrolidone, polymethacrylates, silicate salts and bentonites, and (b) a step of blending with the drug a saccharide of low moldability, wherein the above steps (a) and (b) occur in any order or simultaneously to result in formation of granules. Optionally the process further comprises (c) a step of blending the granules with at least one of a lubricant, a sweetening agent and a flavoring agent to form a tableting blend, and (d) a step of compressing the tableting blend to form oral fast-melt tablets. Also provided is a composition prepared by such a process.
Inventors:
Callari, Tugral Tea
Contney, mark jay
Les, tongue tea
Contney, mark jay
Les, tongue tea
Application Number:
JP2002520808A
Publication Date:
March 04, 2004
Filing Date:
August 17, 2001
Export Citation:
Assignee:
Pharmacia Corporation
International Classes:
A61K9/20; A61K9/00; A61K9/16; A61K31/10; A61K31/122; A61K31/352; A61K31/353; A61K31/365; A61K31/415; A61K31/42; A61K31/444; A61K31/451; A61K31/485; A61K31/50; A61K31/635; A61K45/00; A61K47/02; A61K47/04; A61K47/10; A61K47/14; A61K47/18; A61K47/20; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61P1/04; A61P1/16; A61P5/24; A61P9/00; A61P11/00; A61P11/06; A61P15/00; A61P17/00; A61P19/02; A61P19/10; A61P25/00; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P29/02; A61P35/00; A61P43/00; (IPC1-7): A61K9/20; A61K9/16; A61K31/122; A61K31/353; A61K31/365; A61K31/415; A61K31/42; A61K31/444; A61K31/451; A61K31/485; A61K31/50; A61K45/00; A61K47/02; A61K47/04; A61K47/10; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61P29/00; A61P29/02; A61P43/00
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takako Koiso
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takako Koiso