Title:
経口不活化ワクチン及びそれを提供するための方法
Document Type and Number:
Japanese Patent JP2008509680
Kind Code:
A
Abstract:
There is described a method for selecting microbial isolates for use in oral killed vaccines against abnormal microbial colonization of mucosal surfaces by the microbes. The method comprises evaluating capacity of a plurality of different isolates of a microbe to activate antigen responsive cells to provide activation data for each microbial isolate, and the effectiveness of the isolates in reducing infection of a mucosal surface by the microbe to provide clearance data for each microbial isolate. An isolate, the activation data and clearance data for which correlate and is optimal for generating mucosal immunity against the microbe compared to the, or each, other of the isolates, or an isolate the activation data for which is optimal and a further isolate the clearance data for which is optimal, compared to the, or each, other of the isolates, respectively, is then selected for use in the vaccine. There is also described a method for providing an oral killed vaccine against abnormal microbial colonization of a mucosal surface, comprising evaluating the capacity of a plurality of different isolates of a microbe to induce expression of IL-10 and IL-12 in antigen responsive cells. At least one isolate is selected that induces optimal expression of IL-12 relative to IL-10 compared to the, or each, other of the isolates, respectively, for use in the vaccine.
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Inventors:
Clancy, robert
Philip, Commons
Bread,gerald
Philip, Commons
Bread,gerald
Application Number:
JP2007526121A
Publication Date:
April 03, 2008
Filing Date:
August 17, 2005
Export Citation:
Assignee:
Hunter Immunology Limited
International Classes:
C12N1/00; A61K39/00; A61K39/02; A61K39/04; A61K39/085; A61K39/09; A61K39/104; A61K39/106; A61K39/108; A61K39/118; A61P31/04
Domestic Patent References:
| JP2003533489A | 2003-11-11 | |||
| JP2004502653A | 2004-01-29 |
Other References:
JPN6011009832; Ｊ．Ｃｌｉｎ．Ｅｐｉｄｅｍｉｏｌ．，２００１，５４（１），ｐ．６８-８５
Attorney, Agent or Firm:
Tadahiko Ito
Shinsuke Onuki
Tadashige Ito
Shinsuke Onuki
Tadashige Ito