To provide a method of preventing or treating the state relating to bacillemia, sepsis, septic shock, failure of several organs, acute respiratory distress syndrome (ARDS) etc.

The invention relates to oral administration of solely a lactoferrin composition or together with a standard therapy or a metal chelator for the prevention or treatment of the subsequent symptom of generalized inflammatory response syndrome induced by bacteria, especially the therapeutic use of solely a recombinant human lactoferrin or combined with a metal chelator or other therapeutic medical act.