Title:
シクロスポリン含有経口医薬組成物
Document Type and Number:
Japanese Patent JP2005539002
Kind Code:
A
Abstract:
Disclosed is a pharmaceutical composition suitable for oral administration in the form of a homogeneous solution which on exposure to water or gastrointestinal fluids forms an emulsion having a particle size of less than 5 microns, the solution containing: (a) a pharmaceutically effective amount of a cyclosporin, in particular Cyclosporin A, (b) a carrier medium which is a dialkyl ester of an aliphatic or aromatic dioic acid, the alkyl group of said dialkyl ester having from 2 to 8 carbon atoms, and said aliphatic or aromatic dioic acid having from 6 to 20 carbon atoms, (c) a co-carrier having a hydrophilic lipophilic balance (HLB) of from 3 to 6, and (d) a non-ionic surfactant having a hydrophilic lipophilic balance (HLB) greater than 10. Examples of the carrier medium are dibutyl sebacate and dibutyl phthalate. Examples of the co-carrier are glycerol monooleate, sorbitan monooleate, glycerol monocaprylate, and sorbitan monolaurate.
Inventors:
PATEL, Satishchandra Punambhai
Application Number:
JP2004525534A
Publication Date:
December 22, 2005
Filing Date:
July 31, 2003
Export Citation:
Assignee:
PATEL, Satishchandra Punambhai
International Classes:
A61K9/00; A61K9/107; A61K9/48; A61K38/00; A61K38/13; A61K47/14; A61P29/00; A61P33/00; A61P37/06; (IPC1-7): A61K38/00; A61K9/107; A61K9/48; A61K47/14
Domestic Patent References:
| JPH107550A | 1998-01-13 | |||
| JPH07278007A | 1995-10-24 | |||
| JPH1149664A | 1999-02-23 |
Attorney, Agent or Firm:
Michiteru Soga
Michiharu Soga
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Kazuhiro Oyaku
Michiharu Soga
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Kazuhiro Oyaku