To obtain the subject solid preparation of dihydropyridine that is readily prepared through a simple preparation process, slightly soluble and suitable for long-term storage and is useful for treatment of angina pectoris and hypertension by adding magnesium carbonate to a dihydropyridine compound.
4-Phenyl-1,4-dihydropyridine-3,5-dicarboxylic diester derivative (dihydropyridine compound) (nitrendipine) that has a relatively long half life of the elimination from blood and is slightly soluble is dissolved in an organic solvent (a methylene chloride-ethanol mixed solution), then the solution is adsorbed to magnesium carbonate, then therapeutically inactive components (excipient, binder, disintegrator, lubricant and the like) are added to prepare the objective preparation. The content of a dihydropyridine as an active ingredient, is preferably 3-20wt.%, that of magnesium carbonate is preferably 3-60wt.%. The preparation is free from surfactant. The solid preparation means, for example, tablets, capsules, dust, granules and preferably tablets.
KUMAGAI EIJI
MASUDA HIROTAKA
IIJIMA MASANORI
NIPPON YAKUHIN KOGYO KK
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