To provide an orally disintegrating sustained release tablet containing ambroxol hydrochloride.
An orally disintegrating sustained release tablet is manufactured by: mixing controlled-release fine particles comprising (1) core particles containing ambroxol hydrochloride and a binding agent, (2) a release-controlled layer obtained by mixing a water insoluble polymer and a water soluble polymer which covers the core particles, (3) a protecting layer which is provided outside of the release-controlled layer and contains a water soluble wax type polymer, and (4) controlled-release fine particles composed of an adhesion protecting layer which is provided outside the protecting layer and contains powder that is not dissolved and swelled in the water insoluble polymer and/or water, with quick-release fine particles obtained by covering the core particles containing ambroxol hydrochloride and the binding agent with only the water insoluble polymer or the mixture of the water insoluble polymer and the water soluble polymer so that at least part of ambroxol hydrochloride is released in the stomach; and adding at least a disintegrating agent and a lubricant to the obtained mixture and then compressing and molding.
ONISHI HARUMASA
OSAKI MIYUKI
NAKANO YOSHIO
HAYASHIDA TOMOHIRO
JP2007153887A | 2007-06-21 | |||
JP2012005181A | 2012-01-05 | |||
JP2012153724A | 2012-08-16 | |||
JP2009524698A | 2009-07-02 | |||
JP2007153887A | 2007-06-21 | |||
JP2012005181A | 2012-01-05 | |||
JP2012153724A | 2012-08-16 | |||
JP2009524698A | 2009-07-02 |
WO2012063257A2 | 2012-05-18 | |||
WO2012051333A1 | 2012-04-19 | |||
WO2011066289A1 | 2011-06-03 | |||
WO2012063257A2 | 2012-05-18 | |||
WO2012051333A1 | 2012-04-19 | |||
WO2011066289A1 | 2011-06-03 |
Kazuo Akaoka
Akiko Yoshioka
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