Title:
エステトロールを含有する口腔内崩壊錠
Document Type and Number:
Japanese Patent JP6866561
Kind Code:
B2
Abstract:
The invention provides an orodispersible solid pharmaceutical dosage unit having a weight between 30 and 1,000 mg, said dosage unit containing at least 100 μg of an estetrol component selected from estetrol, estetrol esters and combinations thereof; wherein the solid dosage unit can be obtained by a process that comprises: providing a loading liquid comprising organic solvent; estetrol component and optionally one or more other pharmaceutically acceptable ingredients; mixing 1 part by weight of the loading liquid with 0.5-20 parts by weight of carrier particles to produce wet particles; removing organic solvent from the wet particles to produce loaded particles; optionally mixing the loaded particles with one or more tabletting excipients; and forming the loaded particles or the mixture of the loaded particles and the one or more tabletting excipients into a solid dosage unit. The solid dosage unit is easy to manufacture and perfectly suited for sublingual, buccal or sublabial administration.
Inventors:
Jaspearl, Ceverine Francine Isabel
Plateau, Johannes Jean
Van den Hubel, Denny Joanne Malein
Plateau, Johannes Jean
Van den Hubel, Denny Joanne Malein
Application Number:
JP2017564396A
Publication Date:
April 28, 2021
Filing Date:
June 17, 2016
Export Citation:
Assignee:
S-Tetra Society Preve A Responsabilites Limited
International Classes:
A61K31/565; A61K9/20; A61K47/10; A61K47/26; A61K47/32; A61K47/36; A61K47/38; A61P5/30; A61P15/18
Foreign References:
| WO2015086643A1 | ||||
| WO2002021025A1 | ||||
| US20110250274 | ||||
| WO2004006936A1 | ||||
| US20050070488 | ||||
| WO2004103377A1 |
Attorney, Agent or Firm:
Ikeda adult
Junichiro Sakamaki
Masakazu Noda
Junichiro Sakamaki
Masakazu Noda